Chronic Arsenic Poisoning:  
History, Study and Remediation
 Last updated  July 23rd 2009

Richard Wilson

Countries Books Conferences References
Measurement Site History
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World Map
 Documented cases of arsenic problems in groundwater related to natural contamination (Smedley, Kinniburgh 2001).
Click on any of the annotated hotspots for details.
A map by Amini et al, Swiss Federal Institute of Aquatic Science and Technology, showing the modelled global probability of geogenic arsenic contamination can be found here .

Keratoses of the foot

Arsenic is found in groundwater

of many countries: 
particularly South East Asia
&    Bangladesh
(50 million with arsenic above
new  EPA standard)
Multiple skin cancers
A community meeting discussing
how to get pure water
Dr. Abu Hassam, inventor of the SONO filter has won the $1,000,000  Grainger Challenge Gold Award.

Skin cancers

Summary of the acute and chronic effects of arsenic
and the extent of the world arsenic catastrophe
A brief historical survey

"It is an uncanny thought that this lurking poison (arsenic) is everywhere about us,  ready to gain unsuspected entrance to our bodies from the food we eat, the water we drink and the air we breathe"  Karl Vogel, 1928.

Acute effects
    Arsenic has been used since 3000 BC (Partington, 1935). In the United Kingdom, for example, it was used to extract iron from iron ore.  It has long been known that arsenic is acutely toxic.  Anyone who drinks arsenic in water at 60 parts per million (ppm) will soon die.  There are several toxicological summary references for acute effects available on the web such as SCORECARDASTDR, USEPA and LSUMC.
Beneficial effects
    Arsenic has been used for many years for  medicinal purposes.  It used to be used as a cure for diseases such as syphilis and has been shown to assist in curing some leukemias.  It was taken as a medicine in Fowler's Solution for well over a century. That arsenic at low levels is safe seemed to be reinforced by animal studies that seemed to show that arsenic is beneficial (to animals) at low doses. Indeed, the fact that laboratory animals could not be persuaded to develop cancer misled toxicologists throughout the world and greatly contributed to the present catastrophe.  Others have written about other possible beneficial effects at very low levels. It is important to note that the beneficial effects are for different medical outcomes (end points) than either the acute or chronic adverse effects and that both beneficial and adverse effects can be observed simultaneously (as is well known for alcohol ingestion).  Another detailed article about beneficial uses of arsenic can be found here .  Mineral hot springs in the USA still advertise arsenic pools and their users, including this webmaster, are convinced that the effects are beneficial! (But arsenic penetrates the skin only slowly)

Chronic adverse effects
    Chronic effects of prolonged low level exposure have recently showed up.  Among various summaries we link to an information site run by ASTDR. Skin pigmentation, keratoses and skin cancers were found by  Tseng in Taiwan in 1966 among people who drank from arsenic contaminated wells (but no effect was seen below about 150 parts per billion (ppb),  which might  therefore be a biological threshold) and a very high incidence of lung, bladder and other cancers was found in Taiwan by Dr Chien-Jen  Chen in 1986 and by Dr  Allan  Smith and collaborators in Chile in 1993.  These convinced WHO to  recommend lowering the regulatory level from 50 ppb to 10 ppb for arsenic in water.   It appears that there are no data on humans to contest the idea that prolonged exposure to low doses is dangerous.  Although arsenic was used medicinally in "Fowler's  Solution" (1% arsenite), prolonged use had led to these chronic skin effects.  This was observed as early as 1888 by Hutchinson. A follow up of a number of English patients treated with  Fowler's Solution has been reported by Dr Susan Evans in published literature, in a report at the February 1998 conference in Dhaka  and in a presidential address by Susan Evans to the Liverpool Medical Institute, which is available for download in PDF format.   This shows that the use of "Fowler's solution" (which is primarily medicinal arsenic) in the UK is probably responsible for 5 bladder cancer cases among the patients among  whom only 1.6 were expected  from natural causes. The arsenic dose was equivalent to an average lifetime dose that would come from drinking water with about 25 ppb of arsenic therein.
  After several years of low level arsenic exposure, various skin lesions appear. These are manifested by hyperpigmentation  (dark spots), hypopigmentation (white spots) and keratoses of the hands and feet.  After a dozen or so years skin cancers are expected. Twenty or thirty  years after exposure to 500 ppb of arsenic, internal cancers (lung, kidney,  liver and bladder) appear among 10% of all exposed.  Moreover, the  dose-response relationship for these internal cancers is consistent with being linear with no threshold.  Photographs of a  number of victims  of  this  poisoning  are available both from Bangladesh and from Inner  Mongolia.

    Although the most dramatic effect was the observation of internal cancers in Tawian,  the most extensive epidemiological studies have come from the work in Chile, in which Dr Allan Smith of UC Berkeley has been heavily involved.   They find the extraordinarily surprizing result that ingested arsenic in Chile has produced lung cancer at a rate greater than that of a heavy cigarette smoker!   Recently, the group identified an effect of arsenic exposure to chldren - who have developing lungs -.  Children exposed to arsenic have ten times the normal lung cancer incidence.
. .
The Effect  of  diet

    An important issue for coping with arsenic exposure is the effect of diet.  A general issue can be stated:  there is frequently more than one cause of a cancer or a lesion.  For example lung cancer can be caused by cigarette smoking or asbestos or both together, in a synergistic way such that the risks multiply (rather than add) when both are present.  In the USA it has been found that people who have a good diet of fresh fruit and vegetables (5 servings per day) have half the risk of many cancers, including lung cancers caused by cigarettes, as those without a good diet.  By analogy, one might expect that the lung cancer risk from arsenic will be less among those with a good diet.   Anecdotal indications from Bangladesh suggests that a good diet reduces skin lesions,  and the effect is seen in West Bengal,  but the effect is small and the authors recommend that effort is better spent on obtaining pure water.   Nonetheless  epidemiological studies to confirm this are highly desirable.   Khaliquzzaman and Khan have calculated the  "Arsenic Exposure of Bangladesh Population through  Food Chain" using known amounts in food,  in an unpublished World Bank report.  The amount is less than from drinking water but not much less.

    There are several specific chemicals that have been suggested that would either (i) help to prevent arsenic lesions by rapid removal of arsenic from the body or (ii) help to cure arsenic lesions.  Encouragement of methylation of the arsenic probably accelerates methylation, but the methylation has been suggested as a cause of internal cancers.   The specific chemical that has come to the mind of many health experts is selenium.  It was noted in the 1930s that effects of excess selenium can be counteracted by adding arsenic to the diet because As and Se combine.  Does the inverse take place?  It is reported that areas with high incidence of arsenical lesions have low selenium in the water.  Some victims have low selenium levels.    Does adding selenium to the diet really help, either to prevent the lesions from forming (likely), or to treat them afterwards (less likely)?  We have, with help from others, compiled a list of references and a recent paper on the subject.   Professor Zuberi of Rajshashi University has suggested methionine to reduce the arsenic lesions.  Dr. OGB Nambiar has suggested that ferrous sulphate, after conversion to sulfide by bacteria in the colon, absorbs arsenic and assists safe excretion.  The evidence for these remains indirect, and there may be (as suggested above) competing adverse effects.  Only good epidemiology can tell  and this is under way in several places.

Regulatory limits for continuous exposure.

     The regulatory limits on arsenic exposure were set primarily to be sure that  these acute toxic effects were avoided.  The first regulatory limit of which the webmasters are  aware was set as a result of a public inquiry (subsequent to arsenic being found in beer) of six members chaired by the physicist William Thompson, first Lord Kelvin, in 1903.  They recommended that sake of liquids with more than 100 grains of arsenious oxide per gallon (which works out at about 90 ppb of arsenic or 0.09 ug/l)  This was reduced two fold over the next century and until recently the limit set by Bangladesh, the United Kingdom,  and  the United States  was 50 parts per billion (ppb). But the discovery that there are adverse effects of continuous chronic exposure led WHO to lower their recommendation to 10 parts per billion (10 ppb).  The European Union (EU) plans  to enforce a standard of 10 ppb by 2003.  After  a long travail , on October 31st 2001, the administrator of US EPA confirmed a new standard for drinking water of 10 ppb to be enforced by 2006.   In Australia there does not seem to be a specific regulatory level but there are work rules for those working around mine tailings sites.

   The US EPA has recently come out with an extensive  review of mechanisms of action of Dimethyl Arsenic (DMA) and its possible mechanisms of action.  They cannot rule out a linear dose response at the lowest doses.   It is effectively impossible to reduce the content of arsenic in drinking water to a risk level of one in a million lifetime risk calculated with a linear dose-response relationship, a risk level and a calculational procedure frequently used by the U.S. EPA.  The present 10 ppb standard is perhaps the first in which the U.S EPA explicitly compared costs and benefits and used a value of $6.1 million per calculated life saved.  References to the extensive US national discussion are available on the "countries"  page and in particular the section on travail
The worldwide scope of the catastrophe
  Arsenic contamination has become a problem  in  many  parts of the world.  At first as a result of leaching from mine tailings  in Australia, Canada, Japan, Mexico, Thailand, United Kingdom, and the United  States, but now also from the arsenic in natural acquifers now or recently used for water supply in  Argentina, Bangladesh, Cambodia,  Chile , China, Ghana,  Hungary,  Inner Mongolia, Mexico, Nepal, New Zealand, Philippines, Taiwan, the United States and Vietnam.  Arsenic was also widely used as a  pesticide.  20,000 tons a year was imported into the USA, and perhaps double that amount was used, to spray on crops in the USA alone.  No attention was paid to the ultimate fate of the chemical,and in consequence arsenic now appears in foodstuffs . ( Papers  describing data in some of these countries are listed by country  in  the  list of useful references. )   It  is  important to distinguish the problems in Bangladesh, West Bengal and, to a lesser extent, Inner Mongolia, Chile, Nepal and Vietnam, from the  problems that have been found so far in the rest of the world.   These situations have in common that they are an alluvial plain where arsenic has been brought down from the surrounding hills for millenia. It  seems that no one has looked carefully at similar geological situations such as the Mekong delta or  the Irrawaddy delta.  In most of the world exposures above 50 parts per billion (50 ppb) are rare, and once observed, can easily  be avoided.  But the sheer scale of the problems in Bangladesh dwarfs the imagination.  The catastrophe is much worse than the well known catastrophe of the Chernobyl nuclear power plant accident, the Bhopal isothiocyanate leak  or the Kuwait oil fires.  For 90% of  the Bangladeshi communities,  pure water is still a long time away.

The World Bank has recently completed a study for SE Asia which is available on the web:
 Arsenic Contamination of Groundwater in South and East Asian Countries
Volume I: Policy Report
Full Report (1,038kb pdf)
Volume II: Technical Report
Full Report  (2,879kb pdf)
Paper 1: Arsenic Occurrence in Groundwater in South and East Asia -- Scale, Causes, and Mitigation (715kb)
Paper 2: An Overview of Current Operational Responses to the Arsenic Issue in South and East Asia  (413kb)
Paper 3: Arsenic Mitigation Technologies in South and East Asia (345kb)
Paper 4: The Economics of Arsenic Mitigation (335kb)

    The situation in Bangladesh has received a lot of attention because it is the most important.  The new Bangladeshi government has made the solution of the problem a priority as stated clearly by Prime Minister Begum Khaleda Zia as she opened the special WHO workshop in Dhaka on January 14th -16th 2002.  You are invited to comment upon the recommendations  to the government of Bangladesh from the participants  of that workshop.   Professor Chakriborti  of  Kolkata (Calcutta), a  tireless  and enthusiastic  worker  in the field regularly issues his reports on the Bangladesh situation, has a year 2001 report on Bangladesh which we have also captured in a local file.  Another recent draft summary of the Bangladesh situation  has been circulated for comment by WATERAID

    The best review of the situation in Bangladesh is in the paper by Feroze Ahmed, presented to the International Workshop on Arsenic on January 14-16 2002 in Dhaka.   A recent (2002) review from the NGO forum is copied here from the NAISU website in pdf or html .

Why Does Arsenic Get into the Water?

This is the subject of a whole issue of the journal Applied Geochemistry:
 Bhattacharya, P., A. H. Welch, K. M. Ahmed, G. Jacks and R. Naidu  (Eds.)

Arsenic in Groundwater of Sedimentary Aquifers
Applied Geochemistry, 19(2), 163-260, February 2004
The table of contents, with links to abstracts and full text,

    Arsenic is plentiful in the ground..  Yet it does not awlays appear in the water supply.     Scholars at the Cambridge University Department of Geography have identified the following mechanisms for arsenic entering the water which vary between locations..    Alkali-desorption, Geothermal, Reductive dissolution and Sulphide oxidation.    lthough the worst arsenic catastrophe is in Bangladesh, where 35 million people are exposed to levels above the US EPA standard, the amount of arsenic in the soil is less than in many other areas, including areas such as Massachussets, USA, where it does not, nonetheless, appear in unsafe quantities in ground water.  In most of these areas, such as the delta of the Ganges and Irrawaddy, and the bend of the Yellow river, arsenic has come down from the mountains over millenia, attached itself to iron, forming iron pyrites, and been deposited.   Professor McArthur of UC London argues:   "It becomes increasingly clear that severe arsenic pollution of ground water  in most alluvial aquifers worldwide is driven by the microbially-mediated metabolism of organic matter, with FeOOH acting as the source of oxygen: the oxide is reduced during the process and its sorbed arsenic is released to ground water. Despite the widespread acceptance of this mechanism, much about it remains obscure."   One issue is whether the reduction takes place at the surface before the water filters down to the aquifer in the monsoon (as suggested by group (a) below) or whether it is reduced in the aquifer itself.

Papers describing this mechanism include:
(a)  Two papers were presented by Charles Harvey et al.: "On  the Spatial Variability of Arsenic Contamination in the Groundwater of  Bangladesh; A Geochemical and Hydrological Analysis of Arsenic Mobilization at a Field Site in Bangladesh" and a brief report in Science.  Most recently they suggest that reduction occurs in arsenic ponds before water enters the aquifer 
(b)  The group at Columbia University have also presented a papers on the same topic of which the most recent is:  Redox control of arsenic mobilization in Bangladesh groundwater.  Applied Geochemistry, 19(2), 163-260, February 2004, 201-214.  Y.  Zheng, M. Stute, A. van Geen, I. Gavrieli, R. Dhar, H. J. Simpson, P.  Schlosser and K. M. Ahmed.  
(c)   Professor McArthur and colleagues at UCL in London have several reports available on their webpage of which the following may be downloaded -   Arsenic in groundwater: testing pollution mechanisms for sedimentary aquifers in Bangladesh,   Their most recent paper disagrees with the hypothesis of group (a) that the reduction occurs in ponds
    An older idea was that water was being drained from the aquifer, allowing oxidation.   A recent paper describing arsenic contamination in Perth, Australia - shows that there is one location, in Perth  where pyrite oxidation clearly WAS the source of the As (although there is evidence that anerobic release from Fe oxyhydroxides is also taking place deeper in the aquifer).      But the ideas that pyrite oxidation  is the problem in Bangladesh whether caused  by recent rapid pumping that  allowed for oxidation and release of arsenic, or  by the man-made change in river flow, such as the barrage across the Ganges are now considered  to be untenable. 
    In the Americas, from Alaska in the north, through Crater Lake in Oregon, Mono Lake and Searles lake in California, volcanic lakes in Niceragua and Costa Rica, and on to the Andes, lie a chain of volanic activity that brings arsenic to the surface.   This mecahnism of sulfate reduction in the arsenic-rich soda lakes (Mono Lake and Searles lake) of is being studied in detail by Dr Oremland and his group at the US Geological Survey in Menlo Park.  They attrbute the mechanism to bacteria, but of course different bacteria from those responsible for the reduction of iron pyrites in SE Asia and Bangladesh.   Presumably this is the same mechanism as is responsible for the arsenic pollution in the mountains of Argentine and Chile  where  so much  epidemiological studies have been  made.
Social Issues

  Western experts from developed countries often regard the arsenic pollution problem as a technical problem to be solved by purely technical means.  But that is naive.  There are tremendous social issues which control the ability of anyone to help.  One set of papers discussing ws prepared by the Arsenic Policy Support Unit in Bangladesh, (APSU)  which is now defunct, but these papers are copied on this site.   

Possible solutions to the problems.

    The first and most obvious necessity is to measure the arsenic levels in any ground water that is intended for human use. The next step is to purify the water or, better still, provide an alternate supply of pure water.  The way in which this is done varies from country to country.   In SE ASIA, and Bangladesh in particular, two facets of a solution seem to be agreed..
(1)  There is no one solution for all places and communities.  It is vital to involve the local community in the decision and even more important in the follow up and maintenance.  
(2)   The solution in any community and location must based upon the best possible scientific understanding.  The webmaster has attempted to summarize the possibilities in the remediation page.   Please add and correct.   It is very important to share data and experiences as set out in declarations  from four arsenic conferences in Dhaka held by Dhaka Community Hospital.  Also please comment upon the recommendations of the conference organized by WHO but sponsored by the Bangladesh Government in January 2002.

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